Endo Lab.



Original paper

  • Suzuki T, Iida N, Suzuki J, Watanabe Y, Endo T, Hisabori T, Yoshida M.
    Expression of mammalian mitochondrial F1-ATPase in Escherichia coli depends on two chaperone factors, AF1 and AF2.
    FEBS Open Bio. 2016 Oct 25;6(12):1267-1272. doi: 10.1002/2211-5463.12143.

  • R. Kojima, S. Kajiura, H. Sesaki, T. Endo, and Y. Tamura
    Identification of multi‐copy suppressors for endoplasmic reticulum‐mitochondria tethering proteins in Saccharomyces cerevisiae.
    FEBS Lett. 590, 3061-3070 (2016) DOI: 10.1002/1873-3468.12358

  • S. Arakawa, K. Yunoki, T. Izawa, Y. Tamura, S. Nishikawa, and T. Endo
    Quality control of nonstop membrane proteins at the ER membrane and in the cytosol.
    Sci. Rep. 6, Article number: 30795, doi:10.1038/srep30795 (2016)

  • R. Kojima, T. Endo, and Y. Tamura
    A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro
    Sci. Rep. 6, Article number 20777, doi:10.1038/srep30777 (2016)

  • T. Jores, A. Klinger, L. E. Groß, S. Kawano, N. Flinner, E. Duchardt-Ferner, J. Wo ̈hnert, H. Kalbacher, T. Endo, E. Schleiff, and D. Rapaport
    Characterization of the targeting signal in mitochondrial β-barrel proteins
    Nature Commun. 7, Article number 12036, doi:10.1038/ncomms12036 (2016)

  • N. Miyata, Y. Watanabe, Y. Tamura, T. Endo, and O. Kuge
    Phosphatidylserine transport by Ups2–Mdm35 in respiration-active mitochondria
    J. Cell Biol. 214, 77-88, doi:10.1083/jcb.201601082 (2016)
    ---featured by Bruno Mesmin, "Mitochondrial lipid transport and biosynthesis: A complex balance"(Spotlight), J. Cell Biol. 214, 9-11 (2016)


  • T. Shiota, K. Imai, J. Qiu, V. L. Hewitt, K. Tan, H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T Lithgow, T. Endo
    Molecular architecture of the active mitochondrial protein gate
    Science 349 (6255), 1544-1548 (2015)
    (featured by D. Mokranjac and W. Neupert, Architecture of a protein entry gate (News and Views), Nature 528, 201-202 (2015))
  • Y. Watanabe, Y. Tamura, S. Kawano, and T. Endo
    Structural and mechanistic insights into phospholipid transfer by Ups1–Mdm35 in mitochondria
    Nature Commun. 6, Article number: 7922 (2015)
  • D. Maruyama, T. Endo, and S. Nishikawa
    BiP3 supports the early stages of female gametogenesis in the absence of BiP1 and BiP2 in Arabidopsis thaliana
    Plant Signal Behav. 10 (7) e1035853 (2015)
  • A. Takano, T. Kajita, M. Mochizuki, T. Endo, and T. Yoshihisa
    Cytosolic Hsp70 and co-chaperones constitute a novel system for tRNA import into the nucleus.
    eLife 4, e04659 (2015)


  • D. Maruyama, M. Yamamoto, T. Endo, and S. Nishikawa*
    Different sets of ER-resident J-proteins regulate distinct polar nuclear-membrane fusion events in Alabidopsis thaliana
    Plant Cell Physiol. 55(11),1937-1944 (2014)
  • Y. Tamura*, H. Sesaki and T. Endo
    Phospholipid transport via mitochondria.
    Traffic 15 (9), 933-945 (2014)
  • Q. Zhang, Y. Tamura, M. Roy, Y. Adachi, M. Iijima, H. Sesaki
    Biosynthesis and roles of phospholipids in mitochondrial fusion, division and mitophagy.
    Cellular and Molecular Life Sciences 71, 3767-3778 (2014)

  • F. Koyano, K. Okatsu, H. Kosako, Y. Tamura, E. Go, M. Kimura, Y. Kimura, H. Tsuchiya, H. Yoshihara, T. Hirokawa, T. Endo, E. A. Fon, J. F. Trempe, Y. Saeki, K. Tanaka, and N. Matsuda
    Ubiquitin is phosphorylated by PINK1 to activate parkin.
    Nature 510, 162-166 (2014)

  • Jiyao Song, Yasushi Tamura, Tohru Yoshihisa, and Toshiya Endo
    A novel import route for an N-anchor mitochondrial outer membrane protein aided by the TIM23 complex
    EMBO Rep. 15, 670-677 (2014)

  • H. Okamoto, A. Miyagawa, T. Shiota, Y. Tamura and T. Endo
    Intra-molecular disulfide bond of Tim22 maintains integrity of the TIM22 complex in the mitochondrial inner membrane
    J. Biol. Chem. 289, 4827-4838 (2014)

  • D. Maruyama, T. Sugiyama, T. Endo, and S. Nishikawa
    Multiple BiP genes of Alabidopsis thaliana are required for male gametogenesis and pollen competitiveness.
    Plant Cell Physiol. 55, 801-810 (2014)

  • B. Rahman, S. Kawano, K. Yunoki-Esaki, T. Anzai, and T. Endo
    NMR analyses on the interactions of the yeast Tim50 C-terminal region with the presequence and Tim50 core domain
    FEBS Lett. 588, 678-684 (2014)


  • Y. Tamura and T. Endo
    Unveiling the last missing link of the cardiolipin synthetic pathway in mitochondria (Editorial)
    Aging 6, 392-393 (2013) (online published on June 26, 2013)

  • K. Itoh, Y. Tamura, M. Iijima, and H. Sesaki
    Effects of Fcj1-Mos1 and Mitochondrial Division on Aggregation of Mitochondrial DNA Nucleoids and Organelle Morphology
    Mol. Biol. Cell 24, 1842-1851 (2013)

  • Y. Tamura, Y. Harada, S. Nishikawa, K. Yamano, M. Kamiya, T. Shiota, T. Kuroda, O. Kuge, H. Sesaki, K. Imai, K. Tomii, and T. Endo
    Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
    Cell Metab. 17, 709-718 (2013)

  • O. Nureki, R. Ishitani, T. Yoshihisa, M. Sato, N. Dohmae, D. Mangroo, H. Becker, K. Nozawa, F. Arisaka, S. Kanamaru, and S. Bruno,
    Crystal structure of Cex1p reveals the mechanism of tRNA trafficking between nucleus and cytoplasm
    Nuc. Acid Res. (2013)41, 3901-3914

  • T. Shiota, S. Nishikawa, and T. Endo
    Analyses of protein-protein interactions by in vivo photocrosslinking in budding yeast
    in Meth. Mol. Biol. "Membrane Biogenesis" (eds. D. Rapaport and J. M. Herrmann)pp207-217
    Springer (2013)


  • Y. Tamura, O. Onguka, K. Itoh, T. Endo, M. Iijima, S. M. Claypool, H. Sesaki
    Phosphatidylethanolamine biogenesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins, Ups1p and Ups2p.
    J. Biol. Chem. 287, 43961-43971 (2012)

  • T. Shiota*, M. Maruyama*, M. Miura*, Y. Tamura*, K. Yamano, M. Esaki, and T. Endo
    (* These authors contributed equally to this work.)
    The Tom40 assembly process probed using the attachment of different intra-mitochondrial sorting signals.
    Mol. Biol. Cell 23,3936-3947 (2012)

  • T. Izawa, T. Tsuboi, K. Kuroha, T. Inada, S. Nishikawa, and T. Endo
    Role of Dom34:Hbs1 in non-stop protein clearance for normal organelle protein influx
    Cell Reports 2, 447-453 (2012)

  • T. Izawa, H. Nagai, T. Endo, and S. Nishikawa
    Yos9p and Hrd1p mediate ER retention of misfolded proteins for ER-associated degradation
    Mol. Biol. Cell 23, 1283-1293 (2012)


  • T. Shiota, H. Mabuchi, S. Tanaka-Yamano, K. Yamano, and T. Endo
    In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work
    Proc. Natl. Acad. Sci. USA 108, 15179-15183 (2011)

  • S. Mori, T. Kajita, T. Endo, and T. Yoshihisa
    The intron of tRNA-TrpCCA is dispensable for growth and translation of Saccharomyces cerevisiae.
    RNA 17,1760-1769 (2011)

  • T. Endo, S. Kawano, and K. Yamano
    BamE structure: the assembly of β-barrel proteins in the outer membranes of bacteria and mitochondria
    EMBO Rep. (hot off the press) 12, 94-95 (2011)

  • S.C. Botelho, M. Osterberg, A.S. Reichert, K. Yamano, P. Bjorkholm, T. Endo, G. von Heijne, and H. Kim
    TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane
    EMBO J. 30, 1003-1011 (2011)

  • H. Yamamoto, N. Itoh, S. Kawano, Y. Yatsukawa, T. Momose, T. Makio, M. Matsunaga, M. Yokota, M. Esaki, T. Shodai, D. Kohda, A.E.A. Hobbs, R.E. Jensen, and T. Endo
    Dual role of the receptor Tom20 in specificity and efficiency of protein import into mitochondria
    Proc. Natl. Acad. Sci. USA 108, 91-96 (2011)


  • K. Yamano, S. Tanaka-Yamano, and T. Endo
    Tom7 regulates Mdm10-mediated assembly of the mitochondrial import channel protein Tom40
    J. Biol. Chem. 285, 41222-41231 (2010)

  • T. Mori, C. Ogasawara, T. Inada, M. Englert, H. Beier, M. Takezawa, T. Endo, and T. Yoshihisa
    Dual functions of yeast tRNA ligase in the unfolded protein response: unconventional cytoplasmic splicing of HAC1 pre-mRNA is not sufficient to release translational attenuation
    Mol. Biol. Cell 21, 3722-3734 (2010). (A Highlights from MBoC Selection)

  • M. Ruprecht, T. Bionda, T. Sato, M.S. Sommer, T. Endo, and E. Schleiff
    On the impact of precursor unfolding during protein import into chloroplasts
    Mol. Plant 3, 499-508 (2010)

  • M. Yamamoto, M. Kawanabe, Y. Hayashi, T. Endo, and S. Nishikawa
    A vacuolar carboxypeptidase mutant of Arabidopsis thaliana is degraded by the ERAD pathway independently of its N-glycan.
    Biochem. Biophys. Res. Commun. 393, 384-389(2010)

  • K. Yagawa, K. Yamano, T. Oguro, M. Maeda, T. Sato, T. Momose, S. Kawano, and T. Endo
    Structural basis for unfolding pathway-dependent stability of proteins: vectorial unfolding vs. global unfolding
    Protein Science, 19, 693-702 (2010)

  • Y. Harada, Y. Tamura, and T. Endo
    Identification of yeast Art5 as a multicopy suppressor for the mitochondrial translocator maintenance protein Tam41.
    Biochem. Biophys. Res. Commun. 392, 228-233 (2010)

  • K. Yamano, S. Tanaka-Yamano, and T. Endo
    Mdm10 as a dynamic constituent of the TOB/SAM complex directs coordinated assembly of Tom40.
    EMBO Rep. 11, 187-193 (2010) 

  • D. Maruyama, T. Endo, and S. Nishikawa
    Bip-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana.
    Proc. Natl. Acad. Sci. USA 107, 1684-1689 (2010)


  • S. Mano, T. Miwa, S. Nishikawa, T. Mimura, and M. Nishimura
    Seeing is believing: on the use of image databases for visually exploring plant organelle dynamics.
    Plant Cell Physiol. 50, 2000-2014 (2009)

  • H. Yamamoto, K. Fukui, H. Takahashi, S. Kitamura, T. Shiota, K. Terao, M. Uchida, M. Esaki, S. Nishikawa, T. Yoshihisa, K. Yamano, and T. Endo
    Roles of TOM70 in import of presequence-containing mitochondrial proteins
    J. Biol. Chem. 284, 31635-31646 (2009)

  • Dobrista, A. A., Nishikawa, S., Preuss, D., Urbanczyk-Wochniak, E., Sumner, L. W., Hammond, A., Carlson, A., and Swanson, R. J.
    LAP3, a novel plant protein required for pollen development, is essential for proper exine formation.
    Sex. Plant Reprod. 22,167-177(2009)

  • S. Kawano, K. Yamano, M. Naoe, T. Momose, K. Terao, S. Nishikawa, N. Watanabe, and T. Endo
    Structural basis of yeast Tim40 as an oxidative translocator in the mitochondrial intermembrane space
    Proc. Natl. Acad. Sci. USA 106,14403-14407(2009)

  • T. Endo and K. Yamano
    Multiple pathways for mitochondrial protein traffic
    Biol. Chem. 390, 723-730 (2009)

  • Y. Tamura, T. Endo, M. Iijima, and H.Sesaki
    Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
    J. Cell Biol. 185, 1029-1045 (2009)

  • T. Endo
    Control and alteration of protein traffic in the cell
    in Systems Biology - The Challenge of Complexity
    (eds. S. Nakanishi, R. Kageyama, and D. Watanabe) pp129-134, Elsevier Science, Amsterdam (2009)

  • M. Sakoh-Nakatogawa, S. Nishikawa, and T. Endo
    Roles of protein disulfide isomerase-mediated disulfide bond formation of yeast Mnl1p in ER-associated degradation.
    J. Biol. Chem. 284, 11815-11825 (2009)

  • Y. Tamura, Y. Harada, T. Shiota, K. Yamano, K. Watanabe, M. Yokota, H. Yamamoto, H. Sesaki, and T. Endo
    Tim23-Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import.
    J. Cell Biol. 184, 129-141 (2009)

  • T. Oguro, K. Yagawa, T. Momose, T. Sato, K. Yamano, and T. Endo
    Structural stabilities of different regions of the titin I27 domain contribute differently to unfolding upon mitochondrial protein import.
    J. Mol. Biol. 385. 811-819 (2009)


  • S. Nishikawa, A. Hirata, and T. Endo
    Nuclear inner membrane fusion facilitated by yeast Jem1p is required for spindle pole body fusion but not for the first mitotic nuclear division during yeast mating.
    Genes Cells, 13, 1185-1195 (2008)

  • M. Yamamoto, D. Maruyama, T. Endo, and S. Nishikawa
    Arabidopsis thaliana has a set of J proteins in the endoplasmic reticulum that are conserved from yeast to animals and plants.
    Plant Cell Physiol. 49, 1547-1562 (2008)

  • K. Yamano, M. Kuroyanagi-Hasegawa, M. Esaki, M. Yokota, and T. Endo
    Step size analyses of the mitochondrial Hsp70 import motor reveal the Brownian ratchet in operation
    J. Biol. Chem. 283, 27325-27332 (2008)

  • S. Mano, T. Miwa, S. Nishikawa, T. Miura, and M. Nishimura
    The plant organelles database (PODB): a collection of visualized plant organelles and protocols for plant organelle research.
    Nucleic Acids Res. 36, D929-D937 (2008)

  • T. Makio, S. Nishikawa, T. Nakayama, H. Nagai, and T. Endo
    Identification and characterization of a Jem1p ortholog of Candida albicans: dissection of Jem1p functions in karyogamy and protein quality control in Saccharomyces cerevisiae.
    Genes Cells, 13, 1015-1026 (2008)
  • K. Yamano*, Y. Yatsukawa*, M. Esaki, A. E. A Hobbs, R. E. Jensen, and T. Endo
    Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import.
    J. Biol. Chem. 283, 3799-3807 (2008)
    * These authors contributed equally to this paper.
  • T. Saitoh, M. Igura, T. Obita, T. Ose, R. Kojima, K. Maenaka, T. Endo, and D. Kohda
    Tom20 recognizes mitochondrial presequences through dynamic equilibrium among multiple bound states
    EMBO J. 26, 4777-4787 (2007)


  • T. Momose, C. Ohshima, M. Maeda, T. Endo
    Structural basis of functional cooperation of Tim15/Zim17 with yeast mitochondrial Hsp70.
    EMBO Rep. 8, 664-670(2007)

  • T. Yoshihisa, C. Ohshima, K. Yunoki-Esaki, and T. Endo
    Cytoplasmic splicing of tRNA in Saccharomyces cerevisiae
    Genes Cells 12,285-297 (2007)
  • T. Yoshihisa
    tRNA, new aspects in intracellular dynamics
    Cell Mol. Life Sci 63, 1813-1818 (2006)

  • *Y. Tamura, *Y. Harada, K. Yamano, K. Watanabe, D. Ishikawa, C. Ohshima, S. Nishikawa, H. Yamamoto, and T. Endo
    Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria
    J. Cell Biol. 174, 615-623(2006)
    * : These authors contributed equally to this paper.

  • T. Sato, M. Esaki, J. M.Fernandez, and T. Endo
    Comparison of the protein unfolding pathways between mitochondrial protein import and atomic force microscopy measurements
    Proc. Natl. Acad. Sci. USA, 102, 17999-18004 (2005)

  • S.Nishikawa, G.M.Zinkl, R.J.Swanson, D.Maruyama and D.Preuss
    Callose (β-1,3 glucan) is essential for Arabidopsis pollen wall patterning,but not tube growth
    BMC Plant Biology. 5,22(2005)
  • S. Nishikawa, J.L. Brodsky, and K. Nakatsukasa
    Roles of molecular chaperones in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD).
    J. Biochem. 137, 551-555 (2005)

  • A. Takano, T. Endo, and T. Yoshihisa
    tRNA actively shuttles between the nucleus and cytosol in yeast.
    Science 309, 140-142 (2005)

  • M. Igura, T. Ose, T. Obita, C. Sato, K. Maenaka, T. Endo, and D. Kohda
    Crystallization and preliminary X-ray analysis of mitochondrial presequence receptor Tom20 in complexes with a presequence from ALDH
    Acta Cryst Section F61, 514-517 (2005)

  • K. Yamano, D. Ishikawa, M. Esaki, and T. Endo
    Phosphate carrier has an ability to be sorted to either the TIM22 pathway or TIM23 pathway for its import into yeast mitochondria.
    J. Biol. Chem. 280, 10011-10017(2005)

  • H. Yamamoto, T. Momose, Y. Yatsukawa, C. Ohshima, D. Ishikawa, T. Sato, Y. Tamura, Y. Ohwa and T. Endo
    Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane.
    FEBS Lett. 579, 507-511 (2005)

  • T. Endo
    Protein transport to and within plant chloroplasts
    Endocytobiosis Cell Res. 15, 294-299 (2004)

  • K. Nakatsukasa, S. Okada, K. Umebayashi, R. Fukuda, S. Nishikawa, and T. Endo
    Roles of O-mannosylation of aberrant proteins in reduction of the load for endoplasmic reticulum chaperones in yeast
    J. Biol. Chem. 279, 49762-49772 (2004 )

  • M. Naoe, Y. Ohwa, D. Ishikawa, C. Ohshima, S. Nishikawa, H. Yamamoto, and T. Endo
    Identification of Tim40 that mediates protein sorting to the mitochondrial intermembrane space
    J. Biol. Chem. 279, 47815-47821 (2004)

  • M. Esaki, H. Shimizu, T. Ono, H. Yamamoto, T. Kanamori, S. Nishikawa, and T. Endo
    Mitochondrial protein import: Requirement of the presequence elements and TOM components for precursor binding to the TOM complex
    J. Biol. Chem. 279, 45701-45707 (2004)

  • D. Ishikawa, H. Yamamoto, Y. Tamura, K. Moritoh, and T. Endo
    Two novel proteins in the mitochondrial outer membrane mediate β-barrel protein assembly
    J. Cell Biol. 166, 621-627 (2004)

  • T. Asai, T. Takahashi, M. Esaki, S. Nishikawa, K. Ohtsuka, M. Nakai, and T. Endo
    Re-investigation of the requirement of cytosolic ATP for mitochondrial protein import
    J. Biol. Chem. 279, 19464-19470 (2004)

  • M. Esaki, T. Kanamori, S. Nishikawa, I. Shin, P. G. Schultz, and T. Endo
    Tom40 protein import channel binds to non-native proteins and prevents their aggregation
    Nature Struct. Biol. 10, 988-994 (2003)

  • T. Yoshihisa, K. Esaki, C. Ohshima, N. Tanaka, and T. Endo
    Possibility of Cytoplasmic pre-tRNA Splicing: the Yeast tRNA Splicing Endonuclease Mainly Localizes on the Mitochondria
    Mol. Biol. Cell 14, 3266-3279 (2003)

  • T. Endo, H. Yamamoto, and M. Esaki
    Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles. (Commentary Article)
    J. Cell Science 116. 3259-67 (2003)

  • T. Obita, T. Muto, T. Endo and D. Kohda
    Peptide library approach with a disulfide tether to refine the Tom20 recognition motif in mitochondrial presequences.
    J. Mol. Biol. 328, 495-504 (2003)

  • S. Nishikawa, Y. Terazawa, T. Nakayama, A. Hirata, T. Makio and T. Endo
    Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion
    J. Biol. Chem. 278, 9938-9943 (2003)

  • T. Endo
    Mitochondrial protein flux
    in Genome Science - Towards a New paradigm?
    (eds. H. Yoshikawa, N. Ogasawara, and N. Satoh) pp27-32, Elsevier Science, Amsterdam (2002)

  • H. Yamamoto, M. Esaki, T. Kanamori, Y. Tamura, S. Nishikawa, and T. Endo :
    Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes
    Cell 111, 519-528 (2002)

  • A. Kawai, S. Nishikawa, A. Hirata, and T. Endo
    Loss of the mitochondrial Hsp70 functions causes aggregation of mitochondria in yerast cells.
    J. Cell Sci. 114, 3565-3574 (2001)

  • S. Nishikawa, S. W. Fewell, Y. Kato, J. L. Brodsky, and T. Endo
    Molecular chaperones in the yeast ER maintain the solubility of proteins for retro-translocation and degradation.
    J. Cell Biol. 153, 1061-1070 (2001)

  • K. Nakatsukasa, S. Nishikawa, N. Hosokawa, K. Nagata, and T. Endo
    Mnl1p, an (alpha)-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for endoplasmic reticulum-associated degradation of glycoproteins.
    J. Biol. Chem. 276, 8635-8638 (2001)

  • T. Muto, T. Obita, Y. Abe, T. Shodai, T. Endo, and D. Kohda
    NMR identification of the Tom20 binding segment in mitochondrial presequences.
    J. Mol. Biol. 306, 137-143 (2001)

  • Y. Abe, T.Shodai, T. Muto, K. Mihara, H. Torii, S. Nishikawa, T. Endo, and D. Kohda
    Structural basis of presequence recognition by the mitochondrial protein receptor Tom20
    Cell 100, 551-560 (2000)

  • T. Kurihara, S. Hamamoto, R. E. Gimeno, C. A. Kaiser, R. Schekman, and T. Yoshihisa
    Sec24p and Iss1p Function Interchangeably in Transport Vesicle Formation from the Endoplasmic Reticulum in Saccharomyces cerevisiae
    Mol. Biol. Cell 11, 983-998 (2000)

  • K. Saeki, H. Suzuki, M. Tsuneoka, M. Maeda, R. Iwamoto, H. Hasuwa, S. Shida, T. Takahashi, M. Sakaguchi, T. Endo, Y Miura, E. Mekada, and K. Mihara
    Identification of mammalian TOM22 as a subunit of the preprotein translocase of the mitochondrial outer membrane.
    J. Biol. Chem. 275, 31996-32002 (2000)

  • M. Esaki, T. Kanamori, S. Nishikawa, and T. Endo
    Two distinct mechanisms drive protein translocation across the mitochndrial outer membrane in the late step of the cytochrome b2 import pathway
    Proc. Natl. Acad. Sci. USA 96, 11770-11775 (1999)

  • T. Asai, Y. Shinoda, T. Nohara, T. Yoshihisa, and T. Endo
    Sec-dependent pathway and ΔpH-dependent pathway do not share a common translocation pore in thylakoidal protein transport
    J. Biol. Chem. 274, 20075-20078 (1999)

  • T. Kanamori, S. Nishikawa, M. Nakai, I. Shin, P. G. Schultz, and T. Endo
    Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane
    Proc. Natl. Acad. Sci. USA 96, 3634-3639 (1999)

  • Y. Kubo, T. Tsunehiro, S. Nishikawa, M. Nakai, E. Ikeda, A. Toh-e, N. Morishima, T. Shibata, and
    T. Endo
    Two distinct mechanisms Operate in the reactivation of heat-denatured proteins by the mitochondrial Hsp70/Mdj1p/Yge1p chaperone system
    J. Mol. Biol. 286, 447-464 (1999)

  • M. Yoshida, T. Endo, K. Ito, N. Hosokawa, and K. Nagata
    Dynamics and regulation of the stress response: meeting report on the stress response and molecular chaperones from Kyoto.
    Cell Stress & Chaperones 4, 66-74 (1999)

  • S. Nishikawa and T. Endo
    Reinvestigation of the functions of the hydrophobic segment of Jem1p, a yeast endoplasmic reticulum membrane protein mediating nuclear fusion
    Biochem. Biophys. Res. Commun. 244, 785-789 (1998)

  • M. Oka, M. Nakai, T. Endo, C. R. Lim, Y. Kimata and K. Khono
    Loss of hsp70-hsp40 chaperone activity causes abnormal nuclear distribution and aberrant microtubule formation in M-phase of Saccharomyces cerevisiae.
    J. Biol. Chem. 273, 29727-29737 (1998)

  • T. Nohara, T. Yoshihisa, M. Nakai, and T. Endo
    Cloning and characterization of chloroplast SecY proteins
    Photosynthesis: Mechanisms and Effects vol. IV, 3, 3115-3118
    G. Gerab Kluwer (1998)

  • S. Nishikawa and T. Endo
    The yeast JEM1p is a DnaJ-like protein of the endoplasmic reticulum membrane required for nuclear fusion
    J. Biol. Chem. 272, 12889-12892 (1997)

  • T. Endo
    Roles of molecular chaperones in mitochondrial protein import
    Molecular Chaperones in Proteins: Structure, Function, and Mode of Ation, 435-466
    A. Fink and Y. Goto, Marcel Dekker Inc., New York (1997)

  • T. Endo
    Assembly of thylakoid membrane proteins in chlorplasts
    Membrane Proteins: Structure, Function and Expression Control, 191-197
    N. Hamasaki and K. Mihara, Kyushu University Press / S. Karger AG, Fukuoka / Basel (1997)

  • T. Kanamori, S. Noshikawa, I. Shin, P. G. Schultz, and T. Endo
    Probing the exviroment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking
    Proc. Natl. Acad. Sci. USA 94, 485-490 (1997)

  • J. Iwahashi, S.Yamazaki, T. Komiya, N. Nomura, S. Nishikawa, T. Endo, and K. Mihara
    Analysis of the functional domain of the rat liver mitochondrial import receptor Tom20
    J. Biol. Chem. 272, 18467-18472 (1997)

  • M. Sugita, H. Sugishita, T. Fujishiro, M. Tsuboi, C. Sugita, T. Endo, and M. Sugiura
    Organization of a large gene cluster encoding ribosomal proteins in the cyanobacterium Synechococcus sp. strain PCC 6301: comparison of gene clusters among cyanobateria, eubacteria and chloroplast genomes.
    Genes 195, 73-79 (1997)

  • T. Nohara, T. Asai, M. Nakai, M. Sugiura, and T. Endo
    Cytochrome f encoded by the chloroplast genome is imported into thylakoids via the SecA-dependent pathway.
    Biochem. Biophys. Res. Commun. 224, 474-478 (1996)

  • T. Endo, S. Mitsui, M. Nakai, and D. Roise
    Binding of mitochondrial presequences to yeast cytosolic hsp70 depends on the amphiphilicity of the presequence.
    J. Biol. Chem. 271, 4161-4167 (1996)

  • N. Pfanner, M. G. Douglas, T. Endo, N. J. Hoogenraad, R. E. Jensen, M. Meijer, W. Neupert, G.
    Schatz, U. K. Schmitz, and G. C. Shore
    Uniform nomenclature for the protein transport machinery of the mitochondrial membranes.
    Trends Biochem. Sci. 21, 51-52 (1996)

  • T. Endo, T. Nohara, A. Goto, and M. Nakai
    Roles of Sec proteins in protein transport within chloroplasts.
    in: Research in Photosynthesis: from light to biosphere, vol. III (P. Mathis ed.) pp811-814,
    Kluwer, Amsterdam. (1995)

  • M. Nakai, T. Nohara, D. Sugita, and T. Endo
    Cloning and characterization of sec and ffh genes from the cyanobacterium Synechococcus PCC7942.
    in: Research in Photosynthesis: from light to biosphere, vol. III (P. Mathis ed.) pp505-508,
    Kluwer, Amsterdam. (1995)

  • M. Nakai and T. Endo
    Identification of yeast MAS17 encoding the functional counterpart of the mitochondrial receptor complex protein MOM22 of Neurospora crassa.
    FEBS Lett. 357, 202-206 (1995)

  • T. Endo, S. Mitsui and D. Roise
    Mitochondrial presequences can induce aggregation of unfolded proteins.
    FEBS Lett. 359, 93-96 (1995)

  • T. Nohara, M. Nakai, A. Goto, and T. Endo
    Isolation and characterization of the cDNA for pea chloroplast SecA: evolutionary conservation of the bacterial-type SecA-dependent protein transport within chloroplasts.
    FEBS Lett. 364, 305-308 (1995)

  • T. Endo, Y. Nakayama, and M. Nakai
    Avidin fusion protein as a tool to generate a stable translocation intermediate spanning the mitochondrial membranes.
    J. Biochem. 118, 753-759 (1995)

  • M. Nakai, K. Kinoshita, and T. Endo
    Mitochondrial receptor complex protein: the intermembrane-space domain of yeast MAS17 is not essential for its targeting or function.
    J. Biol. Chem. 270, 30571-30575 (1995)

  • M. Nakai, Y. Kato, E. Ikeda, A. Toh-e and T. Endo
    Yge1p, a eukaryotic GrpE homolog, is localized in the mitochondrial matrix and interacts with mitochondrial hsp70.
    Biochem. Biophys. Res. Commun. 200, 435-442 (1994)

  • M. Nakai, T. Nohara, D. Sugita and T. Endo
    Identification and characterization of the SecA protein homologue in the cyanobacterium Synechococcus PCC7942.
    Biochem. Biophys. Res. Commun. 200, 844-851 (1994)

  • T. Endo, M. Kawakami, A. Goto, T. America, P. Weisbeek and M. Nakai
    Chloroplast protein import: chloroplast envelopes and thylakoids have different abilities to unfold proteins.
    Eur. J. Biochem. 225, 403-409 (1994)

  • M. Nakai, A. Goto, T. Nohara, D. Sugita, and T. Endo
    Identification of the SecA protein homolog in pea chloroplasts and its possible involvement in thylakoidal protein transport.
    J. Biol. Chem. 269, 31338-31341 (1994)

  • M. Nakai, T. Endo, T. Hase, Y. Tanaka, B. L. Trumpower, H. Ishiwatari, A. Asada, M. Bogaki, and H.Matsubara
    Acidic regions of cytochrome c1 are essencial for ubiquinol-cytochrome c reductase activity in yeast cells lacking the acidic QCR6 protein
    J. Biochem. (Tokyo) 114, 919-925 (1993)

  • M. Nakai, A. Takeda, M. L. Cleary, and T. Endo
    The Bcl-2 protein is inserted into the outer membrane but not into the inner membrane of rat liver mitochondria in vitro
    Biochem. Bophys. Res. Commun. 196, 233-239 (1993)

  • M. Nakai, T. Endo, T. Hase, and H. Matsubara
    Intermitochondrial protein sorting: isolation and characterization of the yeast MSP1 gene which belongs to a novel family of putative ATPase
    J. Biol. Chem. 268, 24262-24269 (1993)

  • M. Nakai, T. Takada, and T. Endo
    Cloning of the YAP19 gene encoding a putative yeast homolog of AP19, the mammalian small chain of the clathrin-assembly proteins
    Biochem. Biophys. Acta 1174, 282-284 (1993)

  • M. Nakai, D. Sugita, T. Omata, and T. Endo
    SecY protein is localized in both the cytoplasmic and thylakoid membrane in the cyanobacterium Synechococcus PCC7942
    Biochem. Biophys. Res. Commun. 193, 228-234 (1993)

  • M. Nakai, A. Tanaka, T. Omata, and T. Endo
    Cloning and characterization of secY gene from the cyanobacterium Synechococcus PC7942
    Biochem. Biophys. Acta 1171, 113-116 (1992)

  • T. Endo, K. Kawamura, H. Torii, and M. Nakai
    Conformation of the chloroplast-targeting domain of plastocyanin transit peptide and its interaction with lipid bilayers
    Research in Photosynthesis, Vol. III , 181-184
    Norio Murata, Kluwer, Amsterdam (1992)

  • T. Endo, K. Kawamura, and M. Nakai
    Chloroplast targeting domain of plastocyanin transit peptide can form a herical structure but does not have a high affinity for lipid bilayers
    Eur. J. Biochem. 207, 671-675 (1992)

  • T. Endo
    Co-operative binding of hsp60 may promote transfer from hsp70 and correct folding of imported proteins in mitochondria
    FEBS Lett. 293, 1-3 (1991)


    • T. Endo, K. Yamano, and S. Kawano
      Structural insight into the mitochondrial protein import system
      Biochim. Biophys. Acta (Biomembranes) 1808, 955-970 (2011)
    • T. Endo and K. Yamano
      Transport of proteins across or into the mitochondrial outer membrane
      Biochim. Biophys. Acta (Molecular Cell Research), 1803, 706-714 (2010)
  • T. Endo, K. Yamano, and T. Yoshihisa
    Mitochondrial matrix reloaded with RNA
    Cell (Preview) 142, 362-363 (2010)

  • T. Endo, K. Yamano, and S. Kawano
    Structural basis for the disulfide relay system in the mitochondrial intermembrane space
    Antioxid. Redox Signal. 13, 1359-1373 (2010)

  • T. Endo and D. Kohda:
    Functions of outer membrane receptors in mitochondrial protein import (Review article).
    Biochim. Biophys. Acta 1592, 3-14 (2002)



    • 遠藤斗志也
      (週刊)医学のあゆみ 260, 37-41 (2017.1.7)


    • 塩田拓也,遠藤斗志也
      Japanese Scientists in Science 2015, 59 (2016)
    • 塩田拓也,今井賢一郎,遠藤斗志也
      実験医学 34,591-595 (2016)


    • 塩田拓也,遠藤斗志也
      DOI: 10.7875/first.author.2015.112


    • 吉久 徹
      生化学 85, 89-92 (2013)
    • 遠藤斗志也
      (私のメンター) Gottfried Schatz ミトコンドリア生合成研究の先駆者
      実験医学 31, 937-942 (2013)


    • 塩田拓也,西川周一, 遠藤斗志也
      (Close Up実験法)動的なタンパク質相互作用の「スナップショット」を撮る〜in vivoにおける部位特異的光架橋法
      実験医学30, 1799-1805(2012)


    • 遠藤斗志也,山野晃史,原田佳宗,河野 慎
      実験医学 28, 2059-2064 (2010)


    • 遠藤斗志也,西川周一
      第8章 タンパク質の一生:誕生から死まで

    • 吉久 徹
      蛋白質核酸酵素 54, 2121-2126 (2009)


    • 西川周一
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)921 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 925 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 941(2008)

    • 西川周一
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)966 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 976 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 982 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 992 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編) 1008 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)1020 (2008)

    • 西川周一
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)1066 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)1093 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)1095 (2008)

    • 遠藤斗志也
      「キーワード:蛋白質の一生」蛋白質核酸酵素2008年6月号増刊(遠藤斗志也,小椋光,永田和宏,森和俊,田口英樹,吉田賢右編)1103 (2008)

    • 遠藤斗志也
      生物物理 48, 4-10 (2008)


    • 西川周一,遠藤斗志也
      3.8 ミトコンドリア (第III章 真核生物としての細胞体制)
      酵母のすべて:系統,細胞から分子まで (大隅良典,下田 親編) 65-76,シュプリンガージャパン

    • 吉久徹,遠藤斗志也
      4.1 細胞の構造:概論
      生物物理学ハンドブック (石渡信一,桂勲,桐野豊,美宅成樹編) 193-197,朝倉書店

    • 遠藤斗志也,吉久徹,森和俊,田口英樹

    • 遠藤斗志也,吉久徹,森和俊,田口英樹
      タンパク質の一生:集中マスター (遠藤斗志也,森和俊,田口英樹編) 25-35,羊土社

    • 遠藤斗志也
      タンパク質の一生:集中マスター (遠藤斗志也,森和俊,田口英樹編) 58-66,羊土社

    • 遠藤斗志也
      タンパク質の一生:集中マスター (遠藤斗志也,森和俊,田口英樹編) 130,羊土社
      私のチャレンジしたい化学の未解決問題:オルガネラ構造を自在に操り自らの 手で細胞をつくりたい
      化学62, 20-21 (2007)

    • 吉久 徹
      蛋白質核酸酵素増刊「RNAと生命」51, 2568-2873 (2006)

    • 吉久 徹,高野 晃,遠藤斗志也
      蛋白質核酸酵素増刊「細胞核の世界」51, 2232-2234 (2006)
    • 吉久 徹
      蛋白質核酸酵素 51,48-53 (2006)

    • 西川周一,遠藤斗志也
      第11章(1) タンパク質の膜透過装置
      タンパク質科学:構造,物性,機能, 485-494
      後藤祐児,桑島邦博,谷澤克行,化学同人 (2005)

    • 遠藤斗志也
      田隅三生,浜田嘉昭,放送大学教育振興会 (2005)

    • 遠藤斗志也
      田隅三生,浜田嘉昭,放送大学教育振興会 (2005)

    • 永田和宏,遠藤斗志也
      実験医学増刊23「細胞内タンパク質の社会学」(永田和宏,遠藤斗志也編),2213-2214 (2005)

    • 遠藤斗志也,永田和宏
      実験医学増刊23「細胞内タンパク質の社会学」(永田和宏,遠藤斗志也編),2228-2233 (2005)

    • 遠藤斗志也
      実験医学増刊23「細胞内タンパク質の社会学」(永田和宏,遠藤斗志也編),2272-2275 (2005)

    • 遠藤斗志也,山本林
      実験医学増刊23(永田和宏,遠藤斗志也編),2297-2301 (2005)

    • 西川周一,遠藤斗志也
      細胞工学24,786-790 (2005)

    • 遠藤斗志也
      現代化学 2月号,28-33 (2005)

    • 佐藤健大, 西川周一
      細胞工学 23, 1390-1393 (2004)

    • 西川周一,中務邦雄,遠藤斗志也
      蛋白質核酸酵素増刊「細胞における蛋白質の一生」49, 988-991 (2004)

    • 遠藤斗志也,吉久徹
      総論 蛋白質の移動(真核生物):細胞内の交通管制システムがはたらく仕組み
      蛋白質核酸酵素増刊「細胞における蛋白質の一生」49, 877-888 (2004)

    • 遠藤斗志也,江崎雅俊,山本 林,吉久 徹
      実験医学増刊「細胞内輸送研究の最前線」 21, 1889-1895 (2003)

    • 遠藤斗志也
      実験医学 21, 866-868 (2003)

    • 山本 林・江崎雅俊・遠藤斗志也
      ミトコンドリアトランスロケータの連係プレー:タンパク質配送の迷宮 2つの膜で囲まれたミトコンドリアの問題
      実験医学 21, 880-885 (2003)

    • 吉久 徹・遠藤 斗志也
      朝倉植物生理学講座 3:光合成, 109-116
      佐藤公行, 朝倉書店 (2002)

    • 遠藤 斗志也
      オルガネラ形成と分子シャペロン - 細胞が用意したタンパク質支援システム
      生物の科学 遺伝 14, 96-106 (2002)

    • 西川 周一
      カリオガミー - 生殖における最後の関門
      生物の科学 遺伝 14, 127-137 (2002)

    • 遠藤斗志也・小代俊浩・江崎雅俊
      実験医学 20, 7, 980-986 (2002)

    • 河合明美・西川周一・遠藤斗志也
      日本臨床 60, 増刊号4, 9-13 (2002)

    • 西川 周一・遠藤 斗志也
      分子シャペロンによる細胞機能制御, 66-74
      永田和宏・森正敬・吉田賢右, シュプリンガー・フェアラーク東京 (2001)

    • 吉久 徹・遠藤斗志也
      蛋白質核酸酵素 45, 139-146 (2000)

    • 中井正人、西川周一、遠藤斗志也
      分子シャペロン hsp70 とオルガネラ形成
      生化学 67, 108-122 (1995)

    • 遠藤斗志也
      プロテイントラフィックの第一歩 - 生まれたタンパク質は,どこに,どうやって行けばよいのか
      タンパク質の一生:タンパク質の誕生,成熟から死まで (シリーズ バイオサイエンスの新世紀2), 62-74
      中野明彦・遠藤斗志也, 共立出版 (2000)

    • 西川周一,遠藤斗志也
      6.2.5 酵母の細胞内構造体の調製法
      新版 微生物学実験法, 121-125
      大和田紘一・黒岩常祥・杉山純多・高橋秀夫・徳田 元・渡辺 信, 講談社サイエンティフィック (1999)

    • 遠藤斗志也
      細胞内物質のダイナミズム, pp 65-73
      米田悦啓・中野明彦, 学会出版センター (1999)

    • 西川周一遠藤斗志也
      生物学実験法シリーズ: 遺伝子発現研究法, 43, 257-264
      江尻慎一郎・平秀晴・堤賢一・志村憲助, 学会出版センター (1999)

    • 西川周一・遠藤斗志也
      IV オルガネラの機能解析 4 ミトコンドリア
      酵母ラボマニュアル 酵母分子細胞生物学実験法, pp.191-211
      山本正幸・大矢禎一, シュプリンガー・フェアラーク東京 (1998)

    • 野原哲矢・遠藤斗志也
      in vitro転写・翻訳系を用いたタンパク質合成
      細胞工学別冊 9 (植物細胞工学シリーズ9), 37-45
      中村研三、西村幹夫、長谷俊治、前島正義 監修, 秀潤社 (1998)

    • 遠藤斗志也、淺井健好、金森崇、西川周一
      細胞工学 6, 1275-1281 (1997)

    • 遠藤斗志也
      化学 52, 39-42 (1997)

    • 遠藤斗志也
      生体の科学 46, 324-327 (1995)

    • 遠藤斗志也
      in vitro と in vivo 実験の意味と限界を認識しよう
      化学 50, 210-212 (1995)

    • 遠藤斗志也
      1994 年の化学:タンパク質の水素原子交換を引き起こす「揺らぎ」の実体
      化学 49, 302-303 (1994)

    • 遠藤斗志也
      Annual Review 細胞生物学 1994, 32-44 (1994)

    • 遠藤斗志也
      1993 年の化学:タンパク質のミトコンドリア内での仕分け経路
      化学 48, 68-69 (1993)

    • 遠藤斗志也
      DHFR 融合タンパク質を用いたミトコンドリアタンパク質局在化機構の解析
      新生化学実験講座6 生体膜と膜輸送(下) 733-738, 東京化学同人、東京 (1992)

    • 遠藤斗志也
      高分子 40, 620-623 (1991)

    • 遠藤斗志也
      1991 年の化学:タンパク質の膜透過チャネルの電気生理学的な検出
      化学 46, 651 (1991)

    • 遠藤斗志也、中井正人
      蛋白質核酸酵素 36, 1951-1956 (1991)

    • 遠藤斗志也
      生物物理 31, 13-18 (1991)

    • 遠藤斗志也
      蛋白質核酸酵素 36, 28-36 (1991)